福井大学医学部
福井大学医学部 > 学部・学科・大学院 > 医学部医学科 > 研究業績

分子遺伝学（生化学１）

研究業績

著書・総説等

2017

  1. 菅井 学: 抗体の機能的差異を生み出す分子機構の解析, 上原記念生命科学財団研究報告集（CD-ROM）, (31), ROMBUNNo.39, 201712

2016

  1. Chronic inflammation   :Roles of the Epithelial Autophagy in the Intestinal Mucosal Barrier    Aoki K. and Sugai M.603-616(2016)
  2. 菅井 学: ミトコンドリア機能と活性化B細胞分化, 医学の歩み, 253(13), 1327-1328, 2016

2012

  1. 菅井学、南部由希子、清水章　『制御性T細胞と大腸炎関連発癌』　編集　吉川敏一、浅香正博、千葉勉ら 『G.I. Research』　先端化学社
    Vol２０, 466-471ページ（２０１２）
  2. 菅井学、渡邊翔、南部由希子、林達成、清水章　『IgAへのクラススイッチと転写因子(Runx2/3)』　編集　矢田純一、羅智靖 『臨床免疫・アレルギー科』　化学評論社
    Vol57, 484-493ページ（２０１２）

2011

  1. Sugai, M. #, Watanabe, K., Nambu, Y., Hayashi, T. and Shimizu, A.
    #S.M. corresponding author
    Functions of Runx in IgA class switch recombination.
    J. Cellular Biochemistry, (2011) 112; 409-414. 21268061

学術論文等

2021

  1. A. Murashima-Suginami, H. Kiso, Y. Tokita, E. Mihara, Y. Nambu, R. Uozumi, Y. Tabata, K. Bessho, J. Takagi, M. Sugai, K. Takahashi :Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling :Science Advances(2021)7,7,eabf1798

 

2020

  1. Akira Utsunomiya,Takenao Chino,Natsuko Utsunomiya,Vu HuyLong,Atsushi Tokuriki,Tatsuro Naganuma,Makoto Arita,Kiyoshi Higashi,Kouchi Saito,Noriyuki Suzuki,Ayako Ohara,Manabu Sugai,Daisuke Tsuruta,Noritaka Oyama,Minoru Hasegawa:Homeostatic unction of Dermoskine in the Skin Barrier and Inlammation:J Invest Dermatol.(2019),140,4,838-849,
  2. Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata, Kazuhisa Bessho:Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy :INFLAMMATION AND REGENERATION(2020)40,1,

2019

  1. H.Kiso,K.Takahashi,S.Mishima,A.Murashima-Suginami,A.Kakeno,T.Tamazaki,K.Asai,Y.Tokita,R,Uozumi,M.Sugai,H.Harada,B.Huang,M.MacDougall,K.Bessho:Third Dentition Is the Main Cause o Premolar Supernumerary Tooth ormation,Journal of Dental Reserch(2019),98,9,968-974,
  2. Akira Utsunomiya,Takenao Chino,Natsuko Utsunomiya,Vu HuyLong,Atsushi Tokuriki,Tatsuro Naganuma,Makoto Arita,Kiyoshi Higashi,Kouchi Saito,Noriyuki Suzuki,Ayako Ohara,Manabu Sugai,Daisuke Tsuruta,Noritaka Oyama,Minoru Hasegawa:Homeostatic unction of Dermoskine in the Skin Barrier and Inlammation:J Invest Dermatol.(2019),140,4,838-849,
  3. 菅井　学、南部　由希子: 免疫とミトコンドリア機能, 生命の科学, 70, 114-119, 2019
  4. Katsuhiko Itoh, Gen Kondoh, Hitoshi Miyachi, Manabu Sugai, Yoshiyuki Kaneko, Satsuki Kitano, Hitomi Watanabe, Ryota Maeda, Akihiro Imura, Yu Liu, Chizuru Ito, Shigeyoshi Itohara, Kiyotaka Toshimori, Jun Fujita:Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo:Science Signaling(2019),12,574,
  5. Akari Nitta, Kazuya Hori, Isei Tanida, Ayumi Igarashi, Yasuyo Deyama, Takashi Ueno, Eiki Kominami, Manabu Sugai, Koji Aoki:Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S:Biochemical and Biophysical Research Communications(2019),508,2.521,

2018

  1. Yamazaki Y, Nambu Y, Ohmae M, Sugai M, Kimura S: Immune responses against Lewis Y tumor-associated carbohydrate antigendisplayed densely on self-assembling nanocarriers., Organic & biomolecular chemistry, (2018)16(43), 8095-8105,
  2. Isobe Y, Takahashi K, Kiso H, Nakao K, Ikeno M, Koyama N, Sugai M, Shimizu A, Haga H, Bessho K: Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia., Archives of oral biology(2018), 93, 133-140,
  3. Nitta A., Hori K., Tanida I., Igarashi A., Deyama Y., Ueno T., Kominami E., Sugai M. and Aoki A: Blocking LC3 lipidation andATG12 conjugation reactions by ATG7 mutant protein containing C572S, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS(2018),508(2), 521-526,
  4. Itoh K., Kondoh G., Miyachi H., Sugai M., Kaneko Y., Kitano S., Watanabe H., Maeda R., Imura A., Lin Y., Ito C., Itohara S.,Toshimori K. and Fujita J: Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo,Science Signaling(2018), 12(574), eaao7232,

2017

  1. Tubulointerstitial Nephritis with IgM-Positive Plasma Cells.N.Takahashi，T.Saeki，A.Komatsuda，C.Munemura，T.Fukui，N.Imai，N.Homma，T.Hatta，KI.Samejima，   T.Fujimoto，H.Omori，Y.Ito，Y.Nishikawa，M.Kobayashi，Y.Morikawa，S.Fukushima，S.Yokoi，D.Mikami，K.Kasuno，Ｈ.Kimura，T.Nemoto，Y.Nakamoto，K.Sada，M.Sugai，H.Naiki，H.Yoshida，I.Narita，Y Saito，M.Iwano :Journal of the American Society of Nephrology (2017)28:12:3688~3698   K.Mori，H.Nakamura，H.Miyachi，K.Tamada，M.Sugai，T.Takumi，Y.Yokota
  2. Id2 determines intestinal identity through repression of the foregut transcription factor,Irx5Molecular and cellular biology(2017)R.Ebina-Shibuya，M.Matsumoto，M.Kuwahara，KJ.Jang，M.Sugai，Y.Ito，R.Funayama，K.Nakayama，Y. Sato，N.Ishii，Y.Okamura，K.Kinoshita，K.Kometani，T Kurosaki，A.Muto，M.Ichinose，M.Yamashita，K. Igarashi
  3. Inflammatory responses induce an identity crisis of alveolar macrophages leading to pulmonary alveolar proteinosis.J. Biological Chemistry(2017):292:44:18098~18112K.Saito，K.Takahashi，B.Huang，M.Asahara，H.Kiso，Y.Togo，H.Tsukamoto，S.Mishima， M.Nagata，M.Iida，Y.Tokita，M.Asai，A.Shimizu，T.Komori，H.Harada，M.MacDougall，M.Sugai，K.Bessho
  4. Loss of Stemness,EMT,and Supernumerary Tooth Formation in Cebpb-/-Runx2+/-Murine lncisors Scientific reports (2018):8:1:5169

2016

  1. Y.Togo，K.Takahashi，K.Saito，H.KIso，H.Tsukamoto，B.Huang，M.Yanagita，M.Sugai，     H.Komori，A.Shimizu，M.MacDougall，K.BesshAntagonistic Functions of USAG-1 and RUNX2 during Tooh Development.PLoS One(2016)12;11
  2. O.Takeuchi，A.Konno，H.Takakura，M.Hattori，T.Ozawa: Bioluminescent Indicator for Highly Sensitive Analysis of Estrogenic
    Activity in a Cell-Based Format, Bioconjugate Chemistry, 27(11), 2689-2694, 201611, DOI: 10.1021-acs.bioconjchem.6b00466,
  3. Saito K., Takahashi K., Asahara M., Kiso H., Togo Y., Tsukamoto H., Huang B., Sugai M., Shimizu A., Motokawa M., Slavkin HC.,
    Bessho K: Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis., BMC Dev Biol, 13;16:14, 2016
  4. 斎藤 和幸，高橋 克，喜早 ほのか，東郷 由弥子，三島 清香，GAMEL Dahy Ahamed Khamed Khaled，AGHAZADEH Marziyeh，菅井 学，永田 昌
    毅，原田 英光，別所 和久: マウス切歯体性幹細胞を用いた歯の再生モデル, 再生医療, 16(358), 201702

2015

  1. Jang, K J., Mano, H., Aoki, K. Hayashi, T., Muto A., Nambu, Y., Takahashi, K., Itoh, K., Taketani, S., Nutt, SL., Igarashi, K., Shimizu, A. and Sugai, M.
    Mitochondrial function provides instructive signals for activation-induced B-cell fates
    Nat. Commns. (2015); 6: Article number: 6750: DOI: 10.1038/ncomms7750
  2. Biyajima, K., Kakizaki, F., Shen, X., Mori, K., Sugai, M., Taketo, MM. and Yokota, Y.
    Id2 deletion attenuates Apc-deficient ileal tumor formation
    Biol. Open (2015); 104: DOI: 10.1242/bio.012252
  3. Kim, C J., Hara, E., Shimizu, A., Sugai, M., and Kimura, S.
    Activation of B1a Cells in Peritoneal Cavity by T Cell-Independent Antigen Expressed on Polymeric Micelle
    J. Pharmaceutical Science (2015); 104: 1839-1847
  4. Huang, B., Takahashi, K., Goto, T., Kiso, H., Sugai, M., Shimizu, A. Kosugi, S. and Bessho, K.
    ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents.
    J. Maxillofac. Oral Surg. (2015); 14: 247-251

2014

  1. Kiso, H., Takahashi, K., Saito, K., Togo, Y., Tsukamoto, H., Huang, B., Sugai, M., Shimizu, A., Tabata, Y., Economides, AN., Slavkin, HC. And Bessho, K.
    Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supermumerary Organ Formations.
    PLoS ONE (2014); DOI: 10.1371/journal.pone.009638
  2. Huang, B., Takahashi, K., Jennings, EA., Pumtangon, P., Kiso, H., Togo, Y., Saito, K., Sugai, M., Akira, S., Shimizu, A. and Bessho, K.
    Prospective signs of cleidocranial dysplasia in Cebpb deficiency.
    J. Biomed. Sci.2014 May 13;21:44. doi: 10.1186/1423-0127-21-44.
  3. Naito-Matsui.Y., Takada, S., Kano, Y., Iyoda, T., Sugai, M., Shimizu, A., Inaba, K., Nitschke, L., Tsubata, T., Oka, S., Kozutsumi, Y. and Takematsu, H.
    Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells.
    J. Biol. Chem. (2014); 289: 1564-1579.

2013

  1. Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E., Kimura, S.
    Evasion from accelerated blood clearance of nanocarrier named as “Lactosome” induced by excessive administration of Lactosome.
    Biochim Biophys Acta (2013); 1830: 4046-4052. 23545239
  2. Adachi AA, Fujioka A, Nagano M, Masumoto KH, Takumi T, Yoshimura T, Ebihara S, Mori K, Yokota Y, Shigeyoshi Y. Helix-loop-helix Protein Id2 Stabilizes Mammalian Circadian Oscillation Under Constant Light Conditions.Zoolog Sci;30:1011-1018.2013
  3. H.Kurooka, M.Sugai, K.Mori, Y.Yokota. The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues.Biochem. Biophys. Res. Commun; 433 :579-585.2013

2012

  1. Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Akira, S., Shimizu, A., Bessho, K.
    Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process.
    Oral Disease (2012); 19: 144-150. 22849712
  2. Nambu, Y., Hayashi, T., Jang, K.J., Aoki, K., Mano, H., Nakano, K., Osato, M., Takahashi, K., Itoh, K., Teramukai, S., Komori, T., Fujita, J., Ito, Y., Shimizu, A. and Sugai, M. #
    #S.M. corresponding author
    In situ differentiation of CD8aaT cells from CD4T cells in the peripheral lymphoid tissues
    Sci Rep. (2012); 2: 642. 22962636
  3. Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M. Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.
    Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis.
    Bone, (2012); 50: 69-78. 21985998
  4. Yu, S, Zhou, X, Steinke, F.C, Liu, C, Chen, S.-C, Zagorodna, O, Jing, X, Y.Yokota, Meyerholz, D.K, Mullighan, C.J, Knudson, C.M, Zhao, D.-M, Xue, H.-H. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity;37:813-826.2012
  5. Seré, K, Baek, J.-H, Ober-Blöbaum, J, Müller-Newen, G, Tacke, F, Y.Yokota, Zenke, M, Hieronymus,T. Two distinct types of Langerhans cells populate the skin during steady state and inflammation.Immunity;37;905-916.2012
  6. Kim, D.Y, Fukuyama, S, Nagatake, T, Takamura, K, Kong, I.G, Y.Yokota, Lee, C.H, Kiyono, H,Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model.Allergy;67:502-509.2012
  7. Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, T., Takemoto, M., Sugai, M., Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.: Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis. Bone, 50: 69-78, 2012.
  8. Oh, J., Lee, M.S., Yeon, J.T., Choi, S.W., Kim, H.S., Shim, H., Lee, S.Y., Youn, B.S., Yokota, Y., Kim, J.H. and Kwak, H.B.: Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-fos and Id protein expression. J. Cell. Physiol., 227: 1851-1860, 2012
  9. Kurooka, H., Nakahiro, T., Mori, K., Sano, K. and Yokota, Y.: BMP signaling is responsible for serum-induced Id2 expression. Biochem. Biophys. Res. Com., Biochem. Biophys. Res. Commun.,420:281-287. 2012.

2011

  1. Ishikawa, C., Sawada, S., Nakachi, S., Senba, M., Sugai, M. and Mori, N.
    Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis.
    Carcinogenesis (2011); 32: 110-119. 20974684
  2. Huang, B., Takahashi, K., Sakata, T., Kiso, H., Sugai, M., Fujimura, K., Shimizu, A., Kosugi, S., Sato, T. and Bessho, K.
    Increased risk of TMJ closed lock: a study of ANKH polymorphisms.
    PLOS ONE, (2011); 6: e25503. 22003394
  3. Sugai, M. #,$, Aoki, K. $, Osato, M., Nambu, Y., Ito, K., Taketo, M. M., and Shimizu, A. #
    #S.M. , S.A. corresponding author, $ S.M. and A.K. contributed equally
    Runx3 Is Required for Full Activation of Regulatory T Cells To Prevent Colitis-Associated Tumor Formation.
    J. Immunol. (2011); 186: 6515-6520. 21515792
  4. Jongbloed, M.R., Vicente-Steijn, R., Douglas, Y.L., Wisse, L.J., Mori, K., Yokota, Y., Bartelings, M.M., Schalij, M.J., Mahtab, E.A., Poelmann, R.E., Gittenberger-De Groot, A.C.: Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev. Dyn., 240: 2561-2577, 2011.
  5. Egusa, H., Doi, M., Saeki, M., Fukuyasu, S., Akashi, Y., Yokota, Y., Yatani, H. and Kamisaki, Y.: The small-molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells. Bone, 49: 264-274, 2011.
  6. Kim, D.Y., Sato, A., Fukuyama, S., Sagara, H., Nagatake, T., Kong, I.G., Goda, K., Nochi, T., Kunisawa, J., Sato, S., Yokota, Y., Lee, C.H. and Kiyono, H.: The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J. Immunol., 186: 4253-4262, 2011.

2010

  1. Watanabe, K., Sugai, M. #, Nambu, Y., Osato, M., Hayashi, T. , Kawaguchi, M. , Komori, T. , Ito, Y., Shimizu, A. #
    #S.M. and S.A. corresponding author
    Requirement for Runx proteins in IgA class switching acting downstream of TGF-β1 and retinoic acid signaling.
    J. Immunol. (2010); 184: 2785-2792. 20142360
  2. Identification of BMP-responsive elements in the mouse Id2 gene
    T.Nakahiro, H.Kurooka, K.Mori, K.Sano, Y.Yokota
    Biochem. Biophys. Res. Commun.　2010.08
  3. Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association
    with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia
    cell line.
    N.Hosono, S.Kishi, S.Iho, Y.Urasaki, A.Yoshida, H.Kurooka, Y.Yokota, T.Ueda
    Cancer Sci. 2010.03

学会発表等

2019

  1. 菅井　学: 免疫とミトコンドリア, 19-1バイオ・高分子研究会, あわら市, 20190927

2017

  1. 菅井 学: Mitochondrial function in cell fate determination of activated B cells., 2017年度生命科学系学会合同年次大会, 神戸,201712

2016

  1. 服部 満: ルシフェラーゼ再構成を基盤としたＧＰＣＲシグナルの発光定量検出法, 日本薬学会第137年会 SENDAI 2017, 仙台, 20170325
  2. 服部 満，河村 玄気，小嶋 良輔，神谷 真子，浦野 泰照，小澤 岳昌，: 共焦点発行イメージングを利用した生細胞観察法の開発, 第39回日
    本分子生物学会年会, 横浜市, 20161130
  3. 林　達成、南部　由希子、眞野　浩人、ジャン キョンジン、東雄　二郎、クリスティン ヴァーシェーレン、ダニー ハイレボーエック、清水
    章、菅井　学: Transcription factor Sip1 functions to prevent autoimmunity in the BCR checkpoint of immature B cell stage, 第89
    回日本生化学会大会, 仙台国際センター（宮城県　仙台市）, 20160926
  4. 服部 満: 化学発光イメージングワークショップ, 第2回化学発光イメージングワークショップ, 大阪大学産業科学研究所, 20170208

 

2015

  1. 菅井 学: ミトコンドリア機能による活性化B細胞運命決定機構, 第39回日本鉄バイオサイエンス学会学術集会, 岡山コンベンションセンター
    （岡山県　岡山市）, 20150829
  2. Hayashi T., Nambu Y., Jang KJ., Mano H., Higashi Y., Verschueren K., Huylebroeck D., Shimizu A. Sugai M.: The role of
    transcription factor Sip1 for the repression of Rag genes and its synergistic effect with CD19 on autoimmunity, 日本免疫学会学
    術集会, 札幌コンベンションセンター（北海道　札幌）, 20151119
  3. 林達成, 南部由希子, 眞野浩人, ジャンキョンジン, 東雄二郎, クリスティンヴァーシェーレン, ダニーハイレボーエック, 清水章, 菅井学:
    転写因子Sip1によるIL-7シグナルおよび免疫グロブリン遺伝子組換えの制御, 第88回日本生化学会大会　合同大会, 20151202
  4. Jang, K J., Mano, H., Aoki, K. Hayashi, T., Muto A., Nambu, Y., Takahashi, K., Itoh, K., Taketani, S., Nutt, SL., Igarashi, K.,
    Shimizu, A. and Sugai, M.: Mitochondrial function provides instructive signals for activation-induced B-cell fates., 日本免疫学
    会学術集会, 札幌コンベンションセンター（北海道　札幌）, 20151119
  5. Tatsunari Hayashi: Regulation of IL-7 signaling and immunoglobulin gene recombination by the transcription factor Sip1, 第３８
    回日本分子生物学会, 20151201

2014

  1. Sugai M, Kyoung-Jin Jang , Kazuhiko Igarashi and Akira Shimizu : Mitochondrial function regulates heme oxygenase-1 expression through modulating ability of heme synthesis 8th International Conference on Heme Oxygeneses, BioIron & Oxidative Stress, Sydney, 2014. (Oral presentation)
  2. Sugai M, Kyoung-Jin Jang : B cell-fate determination by mitochondrial ROS via inhibition of heme synthesis 第８７回日本生化学会大会　シンポジウム、2014　（口頭発表）

2013

  1. Irx3/5トランスジェニックマウスを用いた異所性胃上皮形成機構の解析 森　健太郎, 宮地 均, 横田 義史 第36回日本分子生物学会年会
  2. ヒ素による転写抑制因子Id3の核外輸送 黒岡　尚徳, 菅井　学, 森　健太郎, 横田　義史 第86回日本生化学会大会

2012

  1. Id2の欠損はApc遺伝子変異マウスの回腸腫瘍の形成を抑制する 美谷島　杏子, しん　暁東, 森　健太郎, 武藤　誠, 横田　義史 第35回日本分子生物学会年会
  2. 転写調節因子Id2による消化管上皮細胞の運命決定機構 森　健太郎, 中村　ハルミ, 宮地　均, 玉田　紘太, Hui Chi-Chung, 内匠　透, 横田　義史 第35回日本分子生物学会年会
  3. 血清が誘導するId2の発現と筋芽細胞の分化阻害におけるBMPシグナルの役割 黒岡　尚徳, 横田　義史 第35回日本分子生物学会年会

2011

  1. 転写調節因子Id2による消化管上皮細胞の運命決定機構　森　健太郎, 中村　ハルミ, 玉田　紘太, 内匠　透, 横田　義史　第44回日本発生生物学会年会
  2. 転写調節因子Id2による消化管上皮細胞の運命決定機構　森　健太郎, 中村　ハルミ, 横田　義史　日本生化学会北陸支部第29回大会
  3. 転写抑制因子Id2による消化管上皮細胞の運命決定機構　森　健太郎, 中村　ハルミ, 宮地　均, 玉田　紘太, Chi-Chung Hui, 内匠　透, 横田　義史 　第34回日本分子生物学会年会

2010

  1. 酸化ストレスにより形成されるHLHタンパク質の分子間ジスルフィド結合
    黒岡　尚徳, 横田　義史
    第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
    2010.12　神戸

分子遺伝学（生化学１）研究室

TEL
0776-61-8314
FAX
0776-61-8164
メール
msugai@u-fukui.ac.jp